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A common misconception about using prescription drugs is that they’re entirely safe. However, this is far from the truth. In fact, many medications, if misused, can lead to various complications, including addiction. Among these addictive medications is Xtampza ER, a drug that’s prescribed to individuals who suffer from severe pain. This prescription medication is only intended for regular, round-the-clock use, and taking it in ways other than as directed can lead to negative interactions. Keep reading to learn more about Xtampza side effects and what to avoid when taking it. 

What Is Xtampza? 

Xtampza ER is an extended-release opioid that’s prescribed to treat severe or chronic pain. It’s designed for patients who require round-the-clock treatment for their pain and, due to its potency, should not be prescribed for long-term use.   Xtampza is a brand name for the opioid oxycodone, which is otherwise known by brand names like Roxicodone and Oxaydo. Like other opioids, oxycodone (Xtampza) works by attaching to proteins called opioid receptors located on nerve cells in the brain, spinal cord, gut, and other parts of the body. When this occurs, opioids block pain signaling that travels from the body through the spinal cord to the brain.  As a long-acting medication, the side effects of Xtampza extended-release usually last from 12 to 14 hours, providing the user with all-day pain relief. Due to its long-lasting effects,  Xtampza is usually taken once daily.   While Xtampza ER is effective for many patients who suffer from severe or chronic pain, the medication can produce some unwanted side effects and interactions. It’s important to be mindful of your medication’s possible effects before starting treatment.  

Side Effects of Xtampza 


Xtampza ER is a medication that should only be prescribed as an alternative treatment when other opioid painkillers or immediate-release drugs are ineffective or intolerable. This must be kept in mind because opioids place patients at risk of developing a substance use disorder, physical dependence, and long-term misuse.   Furthermore, Xtampza is rarely, if ever, administered to patients with pre-existing gastrointestinal problems like paralytic ileus. This is because the drug may further exacerbate these conditions, especially if used long-term. Patients with biliary tract disease may be prescribed this medication but should be monitored closely for any worsening symptoms.   With this said, common Xtampza side effects include:  
  • Constipation 
  • Nausea 
  • Vomiting 
  • Fatigue 
  • Headache 
  • Dizziness 
  • Abdominal pain 
  • Insomnia  
If taken longer than prescribed or recommended, long-term Xtampza ER side effects like adrenal insufficiency may occur, which is marked by symptoms like tiredness, dizziness, nausea, vomiting, anorexia, and low blood pressure. Abuse and physical dependence are also symptoms Xtampza users must beware of.  

Watching Out for Xtampza Abuse 

All opioids have the potential for abuse and addiction, including oxycodone-based medications like Xtampza. Opioid addiction is the result of misuse, which includes behaviors like crushing and snorting Xtampza pills, taking higher doses than prescribed by a doctor, taking the medication without a prescription, and taking someone else’s medication.   Individuals who become physically dependent on or addicted to opioids may then turn to more dangerous forms of misuse, such as taking them with alcohol. Due to their potency, individuals who abuse opioids like Xtampza are at high risk for overdose. Opioid overdoses have wreaked havoc on the U.S. since the 1990s and, in many cases, have been fatal.   Addiction can take over a person’s life, affecting the individual and the people around them. If someone you know has become addicted to their medication or any other substance, don’t hesitate to reach out to our Christian drug rehabilitation center.  

Treatment for Xtampza ER Abuse 

Opioid addiction can be detrimental to a person’s physical and mental health. Their relationships, career, and finances may also suffer as a result of their drug use. If you or someone you care about has been impacted by addiction, our Christian residential drug rehab can help.    

Call Faith in Recovery today at 888-280-4763 to find out more about our medically assisted detox and opioid addiction treatment to learn how we can aid in your long-term recovery.  



 Related Reading:  
How to Manage Opioid Withdrawal 
How to Overcome a Heroin Addiction with Faith-Based Treatment